I am using IE 11, so I don't know whether or not this is an issue with the script that handles all the stuff on the Canvas in Orchard.Layouts.
I created a Master Layout and then applied it to the stock Welcome to Orchard page. In the Master Layout I put 3 Grids. I populated the Top grid (Header) and Bottom grid (Footer) I created. I left the middle grid empty, expecting to be able to plop the original
page in there some how.
When I navigate to the Content Page, it appears that the original Grid for the page got plopped into my Top grid.
No problem, I figured I'd just move it. However, I cannot. I can select the Grid on the Content Page, but dragging it to another location of the Canvas does not work. I even tried grabbing the Row and individual Columns to see if I could drag / drop.
I don't know if this is an issue, let me know and I will post it.