Yes, I use it everyday. What is specifically your problem?
1) right click to Orchard.Web in Solution explorer and Publish
2) Buil configuration: Debug
Publish method: FileSystem
Target location: xxxx
selected Replace matching files with local copies and publish.
3) create a new web site on IIS and indicate to published data
Server Error in '/' Application.
The resource cannot be found.
HTTP 404. The resource you are looking for (or one of its dependencies) could have been removed, had its name changed, or is temporarily unavailable. Please review the following URL and make sure that it is spelled correctly.
Requested URL: /
How you publish the orchard project?Can you to describe your steps?Thanks!!!